Zhi Yang Presenting “Hierarchical Topic Modeling in Cancer Patients’ Mutational Profiles”

UPDATED: Video Added from the Conference!

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Introducing Zhi Yang > @zhiiiyang < presenting “Hierarchical Topic Modeling in Cancer Research”.

Topic models have been widely applied to extract topics from various range of documents or collections of texts, i.e., online customers reviews, medical records, scientific
journals, legal documents, books and etc. Its application facilitates the process for us to quickly understand the most featured and commonly shared information embedded texts without actually reading through the entire collection. In addition, topic models also allow us to access the contribution of each topic and its representations across different documents. Human genomes have been exposed to an assortment of mutational processes by contributing to unique patterns of somatic mutations. What would happen if we apply the same concept to the somatic mutations obtained from the cancer patients and look for “topics” of mutations? What would these “topics” tell us about the most important information for our health, genetic, risk factors for cancer and
something more that slip under the radar?

Shiraishi et al’s have proposed a topic model targeted for somatic mutations to capture the characteristics and burdens contributed by mutational processes. By closely examining the burdens, we’d like to compare them across different categories, say, for example, time, cancer subtype, ethnicity, smoking history, etc. Then, we’d like to develop the statistical machinery to infer the difference between the mutational profiles across different categories and associate the variations with the know exposures. This tool is potentially useful for identifying novel and existing mutational processes and correlating them with risk factors in which later can be used to monitor any treatment effects in personalized medicine and targeted therapy.

Read the publication here at biorxiv and come check out Zhi Yang’s talk at ML4ALL happening April 28th-30th in amazing Portland, Oregon! Get your tickets to attend here. For the schedule, our excellent sponsors docs for the conference, check out the ML4ALL Conference Site!

ML Spends A Year In Burgundy with Jon Oropeza at ML4ALL

We’re building up to ML4ALL 2019, and in the meanwhile I want to re-introduce some of the past speakers and show you their talks. This first, of the many, is Jon Oropeza. I introduced him last year here, so check out his talk and work, he’s got a lot of good stuff he’s put together!.

The Talk

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ML4ALL Speakers – Meet Paige & Suz

Hello everybody and especially the upcoming ML4ALL attendees! For those that haven’t registered, here’s the link for that, and for those that have welcome aboard! Here’s two of the excellent speakers that will be presenting at ML4ALL Paige (@DynamicWebPaige) and Suz (@Noopkat)!

Paige & Suz both work on the amazing, now somewhat famous Microsoft Developer Advocacy team others like Peter Bright (@drpizza) wrote about in “Microsoft’s renewed embrace of developers developers developers” and James Governor (@monkchips) wrote in “On Hiring Jesse Frazelle: Microsoft’s developer advocacy hot streak continues” and I even wrote a blurb about many months ago. They’ve added even more awesome to a great team and will be coming to ML4ALL to do more of that.

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